The 2001 Ted Demme film “Blow” was shot in Southern California. The home of George’s parents, played by Ray Liotta and Rachel Griffiths, is supposedly located in Massachusetts, but can be found in Whittier.

LOCATION: 6216 Friends Ave, Whittier, CA 90601
The alley where young George rollerskates is located nearby, next to 5839 Friends Ave, Whittier, CA 90601 (GPS coordinates: 33°59’19.7″N, 118°02’04.0″W)
The film jumps ahead to George as an adult, played by Johnny Depp, moving in with Tuna, played by Ethan Suplee. The home they’re seen in has since been completely demolished, with another home standing in it’s place. It was formerly located to the right in the image below.

LOCATION: 5361 E Ocean Blvd, Long Beach, CA 90803 (demolished)
The surrounding buildings all still match up, however, such as this shot of Tuna walking down the sidewalk.

The two go to the beach and meet many women, who all say they are stewardesses. These scenes were filmed near Near Lifeguard Tower 42 St at El Porto Beach, Manhattan Beach, CA 90266 (GPS coordinates: 33°54’11.4″N, 118°25’19.4″W). The El Segundo Power Plant is visible in the background.
The salon where Derek Foreal, played by Paul Ruebens works, can be found at 147 Richmond St, El Segundo, CA 90245.
George is seen smuggling drugs at what is supposed to be LAX. These scenes were actually filmed at Ontario Airport in Ontario, California. This terminal is not in active use and has popped up in countless other films, including “Saving Mr. Banks,” “Zodiac,” “Catch Me If You Can,” “Argo” and many more.

LOCATION: 1940 Moore Way, Ontario, CA 91761
After being released from prison, George makes a call to Diego, played by Jordi Mollà, from a payphone in front of this liquor store.

LOCATION: 506 Center St, El Segundo, CA 90245
George makes a drug deal at a motel, supposedly located in Miami. The motel was actually located at 2010 E Ocean Blvd, Long Beach, CA 90803, but has since been demolished.
After Diego’s wedding, George embraces Mirtha, played by Penélope Cruz, in the lobby of the famed Millennium Biltmore Hotel in Downtown L.A. The hotel is a staple of film, having appeared in such movies as “Ghostbusters,” “Independence Day,” “Fight Club,” “Species,” “Blonde,” “Enough,” “Cheaper By The Dozen,” “Oppenheimer” and many more.

LOCATION: 506 S Grand Ave, Los Angeles, CA 90071

George and Mirtha move into a mansion in Beverly Hills. The home is not visible from the street, but here is an aerial view.

LOCATION: 918 N Alpine Dr, Beverly Hills, CA 90210
George and Diego get into an argument during a drug deal at the Holiday Lodge near Echo Park, located at 1631 W 3rd St, Los Angeles, CA 90017.
The story jumps ahead 3 years and George is seen speaking to his daughter Kristina, played by Emma Roberts, outside her school. These scenes were filmed at Madison Elementary School, 515 E Ashtabula St, Pasadena, CA 91104.
Late in the film, Mirtha is seen living at this home in Pasadena.

LOCATION: 858 N Oakland Ave, Pasadena, CA 91104